Clotrimazole Loaded Topical Gels: Formulation, Development and In-vitro Evaluation

Abstract

The present study aimed to formulate and evaluate clotrimazole topical gel. Clotrimazole topical gel was prepared by dispersion method by utilizing various gelling agents like Carbopol 934p, HPMC K100, and Sodium alginate in three different ratios to achieve desired drug release. Prepared six gel formulations of clotrimazole were evaluated for pH, Viscosity, Drug content, Drug diffusion studies, and Drug release kinetic studies. The Drug-polymer compatibility reports have been done by FTIR absences of extraneous interactions among excipients. CTZGF4 releases 99.53% of the drug at the end of 8 hours and was considered as the best formulation. Therefore, formulations containing Carbopol produced better results than other formulations.