Formulation and evaluation of a novel controlled release meloxicam-loaded organized

Abstract

Based on pluronic lecithin, P.L.O. gels were established in the present research as a topical carrier for the regulated delivery of Meloxicam. Every P.L.O. gel composition was discovered to have pH values between 5.57 and 5.62, which falls within the pH range that skin. The spreadability of organogels from F1 to F4 (25.09-23.41 g.cm/s) decreased due to lecithin. The F5 through F8 saw an increase in the percentage of pluronic (22.45-21.44 g.cm/s). The range of the viscosity of gel formulations was determined to be between 1825 and 3732 cps (F1-F4) and 2136-3663 cps (F5–F8). Eight different organized formulations' gel transition temperatures were measured among such ranges of 32.3^oC and 33.2^oC (F1-F4) and 27.4 - 33.6^oC (F5 – F8). The formulations of F2 and F3 have been chosen for kinetic tests and stability studies because they had the most significant percentage of drug content and the highest drug release during eight hours, and all physical parameters were found to be within acceptable limits. It was discovered that the order of release of drug through different formulations was F1 – F8. A drug is released from the improved formulation F2 regulated according to zero order rate kinetics. The optimized Meloxicam organogel in-vivo anti-inflammatory effectiveness against a commonly used commercial product (ZCLO-CM gel) was satisfactory but also significant.