Evaluation of anti-hypertensive activity of trachyspermum ammi seeds extract on albino rats

Abstract

The study evaluates the antihypertensive activity of Trachyspermum ammi seed extract in albino rats. A preliminary phytochemical analysis identified the presence of steroids, alkaloids, glycosides, carbohydrates, flavonoids, and saponins in the extract. No mortality or behavioral abnormalities were observed during the experiment, confirming the extract's safety at administered doses.Nifedipine, a standard antihypertensive drug, significantly reduced blood pressure parameters, serving as a positive control. Hypertension was induced in DDS model rats using an 8% NaCl method. The ethanolic extract of T. ammi (EET) at a high dose significantly reduced systolic, mean, and diastolic blood pressure, indicating a dose-dependent antihypertensive effect.Phytochemicals such as alkaloids, glycosides, flavonoids, and saponins, known for their antihypertensive properties, are likely responsible for this activity. These compounds may act through mechanisms like vasodilation, diuretic effects, or modulation of vascular resistance.The findings highlight the potential of T. ammi as a natural antihypertensive agent. Further research focusing on isolating and characterizing its active constituents is needed to elucidate their mechanisms and therapeutic applications. Such studies could contribute to the development of plant-based treatments for hypertension, providing an alternative or complementary option to conventional drug therapies.