Formulation Development and Characterization of Floating Drug Delivery System of Rosiglitazone Maleate

Abstract

In the current study, wet granulation with various concentrations and combinations of excipients like magnesium stearate as a lubricant, talc as glident, DCP as diluent, and PVP K 30 as a binder successfully produced floating tablets of rosiglitazone maleate. These excipients included HPMC K15M, xanthan gum, sodium bicarbonate, and tartaric acid as gas-generating agents. We investigated every pre-compressional parameter, including angle of repose, bulk density, and Carr's index. Drug content, hardness, friability, weight fluctuation, in-vitro dissolving experiments, floating qualities, and stability investigations were performed on the compressed tablets. According to in-vitro experiments, the release time increases up to 6, 8, and 10 hours, respectively, as the content of HPMC K15M in formulations F1, F2, and F3 is raised. For formulations F4, F5, and F6, adding xanthan gum raised the release to 7, 9, and 11 hours, respectively. In formulations F7, F8, and F9, the release was found to be increased up to 8, 10, and 12 hours, respectively, with the addition of HPMC K 15 M and Xanthan gum. F9 was discovered to be the finest formulation since it could maintain release for up to 12 hours. All formulations displayed "n" value for Peppa's plot in the range of 0.45 to 0.89, demonstrating anomalous transport (non-Fickian diffusion) as the method of drug release. The improved formulation (F9) was demonstrated to be stable and intact without any contact over the course of 90 days.