Development and description of mouth-dissolving drug delivery system
DOI:
https://doi.org/10.26452/fjphs.v4i2.622Keywords:
Drug delivery system, Oral route, Mouth Dissolving, Anti inflammatory ActivityAbstract
Fast-dissolving oral films (FDOFs) offer superior comfort and flexibility as they dissolve in the oral cavity upon contact with saliva within minutes, enhancing the efficacy of active pharmaceutical ingredients (APIs) without the need for chewing or drinking. Epilepsy, a neurological disorder, requires prompt seizure management. Lamotrigine (LMG), a novel antiepileptic drug, treats various types of seizures. Complexing LMG with ?-cyclodextrins enhances solubility and masks its bitter taste. Researchers developed and evaluated fast-dissolving lamotrigine films to improve palatability and bioavailability, aiming to shorten epileptic seizure duration. Nine initial formulations were created using a solvent-casting process. These formulations underwent rigorous evaluation for physico-chemical properties, including drug content, tensile strength, weight and thickness uniformity, folding endurance, elongation percentage, moisture content, in-vitro disintegration time, and dissolution characteristics. This study aims to enhance the effectiveness and patient acceptability of lamotrigine through innovative FDOF formulation techniques.
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