S adenosyl L methionine's antioxidant and anti-inflammatory characteristics have a cardioprotective effect on Metoprolol-induced chronic heart failure in Wistar rats
DOI:
https://doi.org/10.26452/fjphs.v5i2.724Keywords:
S adenosyl L methionine, antioxidant, anti-inflammatory, cardioprotective effect, Metoprolol, chronic heart failureAbstract
Oxidative stress and myocardial inflammation are closely linked to the onset and progression of chronic heart failure (CHF), hypertrophy, and remodeling. S-adenosylmethionine (SAMe), a dietary supplement with anti-inflammatory and antioxidant properties, has been shown to enhance ventricular remodeling by regulating angiogenesis and fibrosis. This study aimed to evaluate the cardioprotective effects of SAMe in Metoprolol (MPL)-induced CHF and its anti-inflammatory and antioxidant properties.Following animal ethics approval, CHF was induced in 24 Wistar rats by administering MPL (10 mg/kg) for 14 consecutive days. The rats were divided into four groups: Sham Control, Disease Control (DC), MPL + SAMe 100 mg, and MPL + SAMe 200 mg. Evaluations included histology, PET imaging, 18F-FDG biodistribution in heart tissue, glutathione (GSH) and tumor necrosis factor ? (TNF-?) levels, and heart-to-body weight ratio (HW/BW mg/g).SAMe significantly reduced HW/BW compared to DC (P < 0.001) and decreased 18F-FDG uptake in CHF-induced rats (P < 0.001). TNF-? and GSH levels were markedly elevated in both SAMe-treated groups (P < 0.001). Histology showed reduced inflammation and necrosis. SAMe demonstrated cardioprotective effects in MPL-induced CHF due to its anti-inflammatory and antioxidant properties.
