evaluation of anti-diabetic activity of euphorbia neriifolin linn. in the experimentally induced diabetic animal model

Abstract

Ethanolic extract of 400 mg/kg b.wt, Euphorbia neriifolia Linn. was administered orally to Wistar albino rats of both sexes. Glibenclamide 2.5 mg/kg was used as a standard drug to compare extract potency. Body weight, Oral Glucose Tolerance Taste (OGTT), serum lipid profile, fasting blood glucose (FBG), hepatic glycogen, serum insulin, and glycated hemoglobin were evaluated. In OGTT, the decline in fasting blood glucose content occurred 60 minutes after administration of the extract. Euphorbia neriifolia ethanolic extract (ENEE) produced a significant dose-dependent decrease in FBG. After the end of the treatment, the 15th-day dose of ENEE is 400 mg/kg. After two weeks, the animals were given established repeated oral administration of the ENEE at FBG levels, and after 21 days, ENEE produced a dose-dependent decrease in body weight, FBG, triglycerides, total cholesterol, LDL, VLDL; there was a significant increase in HDL content and liver glycogen as a standard drug glibenclamide 2.5 mg/kg was used to compare the potency of the extract. In OGTT reduction, FBG levels were observed after sixty minutes of extract administration. After treatment, The data concluded that ENEE showed dose-dependent anti-diabetic potential and a potent antihyperlipidemic effect.