Formulation and evaluation of amoxapine mucoadhesive buccal films

Authors

  • Mahaboob Ali Sk. Department of Pharmaceutics, Saastra College of Pharmaceutical Education & Research, Near Varigonda Jwalamukhi Temple, Muthukur Road, Kakupalli, Nellore-524311 Andhra Pradesh, India.
  • Swathi Krishna KV Department of Pharmaceutics, Saastra College of Pharmaceutical Education & Research, Near Varigonda Jwalamukhi Temple, Muthukur Road, Kakupalli, Nellore-524311 Andhra Pradesh, India
  • Gautham Chakra R Department of Pharmacy Practice, Saastra College of Pharmaceutical Education & Research, Near Varigonda Jwalamukhi Temple, Muthukur Road, Kakupalli, Nellore-524311 Andhra Pradesh, India

DOI:

https://doi.org/10.26452/fjphs.v4i3.629

Keywords:

Buccal Films, Mucoadhesive, Bioadhesive, Amoxapine

Abstract

Among innovative drug delivery methods, buccal mucoadhesive systems have been attracting much interest recently because of their capacity to stick to the oral mucosa, stay there, and gradually release their drug content. By improving medication absorption through the oral mucosa and reducing the hepatic first-pass impact, buccal mucoadhesive films can increase the drug's bioavailability and enhance its therapeutic effect. The current study aimed to synthesize the medicine as a buccal bioadhesive film, which reduces the frequency of dosage form administration by releasing the drug at a sufficient concentration over time. Because this formulation is simple to administer and requires no water to swallow, improved patient compliance is one of its benefits. Dissolving profile as investigated in USP dissolving apparatus type 1 using saliva at pH 6.8. The impact of factors such as polymer type, concentration, and release profile of Amoxapine was investigated. The formulation was optimized Based on several evaluation criteria, including drug content and in-vitro drug release. Formulation F6 successfully releases the drug in 7 hours. The stability studies followed ICH recommendations, and the results showed that the optimized formulation was stable. The IR spectra demonstrated the stable qualities of Amoxapine in a mixture of polymers utilized and revealed the absence of interaction between the drug and the selected polymer.

Downloads

Download data is not yet available.

Downloads

Published

2024-07-08

How to Cite

Sk. , M. A., KV, S. K., & R, G. C. (2024). Formulation and evaluation of amoxapine mucoadhesive buccal films. Future Journal of Pharmaceuticals and Health Sciences, 4(3), 37–48. https://doi.org/10.26452/fjphs.v4i3.629

Issue

Section

Original Articles

Most read articles by the same author(s)