Solid Lipid Nanoparticles: A New Drug Delivery Formulation Approach

Abstract

Solid lipid nanoparticles, that have numerous powerful advantages for clinical therapy, drug transportation, investigation, as well as a large array of many other fields of science, are among the forefront of a quickly developing field of nanotechnology. Lipid nanoparticles also have potential to contribute to the creation of novel therapeutics because of their unique size-dependent properties. Opioids can now be added to nanocarriers, creating a novel drug delivery prototype which could be used for therapeutic targeting at the secondary and tertiary levels. So, because solid lipid nanoparticles have a great deal of potential for attaining the goal of controlled and site-specific drug delivery, researchers are particularly interested in them. This paper examines a variety of solid lipid nanoparticles and discusses their advantages, disadvantages, as well as potential remedies. The various types of lipid-based solid nanocarriers, including lipid drug conjugates, solid lipid nanoparticles, and nanostructured lipid carriers, are presented along with their structural variations. Solid lipid nanoparticles can be produced in a variety of ways and for a variety of purposes on a large scale. The appropriate analytical techniques, such as scanning electron microscopy, photon correlation spectroscopy, and differential scanning calorimetry, for characterising solid lipid nanoparticles are highlighted. Additionally taken into account are the solid lipid nanoparticle delivery strategy and biodistribution. If thoroughly investigated, solid lipid nanoparticles could completely alter how difficult diseases are treated.