Formulation and evaluation of luliconazole liposomal gel

Abstract

This investigation presents an innovative formulation and evaluation of luliconazole liposomal gel, designed to effectively bypass first-pass metabolism, improve bioavailability, and enhance the drug release mechanism for targeted drug delivery. Utilizing the physical dispersion method with varying lipid concentrations in chloroform, we successfully developed liposomes that were converted into a gel, creating a superior transdermal drug delivery system. We generated eight distinct liposomal gel formulations, each undergoing comprehensive evaluation studies, including identification, drug-polymer compatibility, solubility, morphological characteristics, particle size, drug content, zeta potential, entrapment efficacy, spreadability, and pH assessments. The results demonstrated that our liposomes were uniformly spherical and free of incompatibility. The zeta potential measurements ranged from -42.5 mV to -32 mV, and the entrapment efficacy was impressive, ranging from 65.49% to 84.02%. Furthermore, the particle sizes varied between 262.58 nm and 654.06 nm. With a pH below 5.5 and a viscosity ranging from 42510 to 63768 cps, our liposomal gel showcased excellent spreadability. Notably, these formulations exhibited zero-order kinetics with non-Fickian diffusion, establishing a reliable and sustained drug release profile that underscores the potential of this innovative delivery system.