Formulate and evaluate triamcinolone loaded microsponges for colon drug delivery

Abstract

The study aims to formulate and evaluate in-vitro and pharmacokinetic analyses of microsponges loaded with triamcinolone for colon drug delivery. This study intended to deliver drugs specifically to the colon by creating microsponges filled with triamcinolone. Eudragit RS 100 was used as a polymer to make the microsponge formulations in a quasi-emulsion solvent diffusion technique. It was observed that a time-dependent polymer blocked up to four hours of measurable drug release. At pH 6.8, the pH of the colon, Eudragit RS 100, a sustained release polymer, was found to be present, leading to maximum release. The drug: polymer ratio significantly influences the drug release rate. It has been demonstrated that the highest drug release occurs with a more fantastic drug: polymer ratio. Other microsponges are stable under storage conditions. The produced microsponges have been shown to have a more extended retention period in the colon and good mucoadhesion qualities, indicating that they would be the best dosage form for colon targeting. Microsponges provide the colon with an adequate dosage and, more precisely, controlled release because of their porosity.