Metformin hydrochloride: The most prescribed treatment for type II diabetes -gets banned

Abstract

Metformin hydrochloride (MH) is synthesis of N, N-dimethylguanidine medicament which is used for the treat of type-II diabetes which was discovered by Emil Werner and James Bell, which belongs to BCS class III. MH is chosen first-line oral blood glucose-lowering medication for the treatment of type-II diabetes, almost around 120 million patients are using worldwide. It works by decreasing the hepatic glucose production through a mild inhibition of mitochondrial respiration chain complex. MH which has been further tested and also proven that it can be used for various treatments such as, weight loss, improving fertility, slow the growth of tumour, anti-malaria, and few others. MH is synthesis from Galega officinalis which is a perennial plant that blooms in the summer and is native to most temperate areas. In this study, complete information about the drug history, drug profile, pharmacokinetic, drug interaction, clinical symptoms, advantages & disadvantages of MH and reason why its getting banned has been explained in detail.