Formulation and evaluation of moxifloxacin loaded ocular In-situ gels

Abstract

Moxifloxacin, a fourth-generation broad-spectrum antibiotic, is at the heart of this research, aimed at treating infective ophthalmitis through sustained release via ion-sensitive ocular in-situ gels. The study emphasizes the importance of careful polymer and drug selection for effective oral in-situ gel formulation. Sodium alginate and HPMC were identified as compatible polymers with Moxifloxacin, as confirmed by IR and UV analyses. The concentration of these polymers significantly influences the gel's viscosity, spreadability, and drug release properties. Among the tested formulations, F4 emerged as superior, exhibiting the highest drug release and favorable rheological properties. This formulation not only showed good stability and uniformity but also resulted in better and faster patient improvement. Although the current results are promising, further pharmacokinetic studies are suggested. The F4 formulation outperformed others in efficacy, making it the most optimal choice. In vitro release studies validated the effectiveness of the Moxifloxacin gel formulations used in this research. The extended drug delivery system developed here has the potential to enhance the bioavailability of the medication, thereby improving patient efficacy, compliance, and overall therapeutic value.