Case Report on Isoniazid Induced Lupus Erythematosus: An Autoimmune Phenomenon

Abstract

Drug-Induced Lupus is an autoimmune disorder (DIL) sharing similarity with Systemic Lupus Erythematosus (SLE) which is characterized by the production of autoantibodies. DIL is a little different phenomenon where a drug exposure leads to the development of SLE and the symptoms are usually resolved with the discontinuation of the offending agent. A Tuberculosis Patient was consulted the physician with chief complaints of fever and skin rash associated with erythema since 4 days. He is on Anti TB medication therapy (RIPES) since 6 months. After the detailed investigations, it is found that antinuclear antibodies were elevated and seemed to be Lupus. Isoniazid was suspected as a culprit drug in this case with supporting references. De-challenging of Isoniazid improves the patient health and resolved from the symptoms of SLE.