Wound Healing Potential of Ethanolic Extract of Roots of Glycyrrhiza glabra L. in Diabetes Induced Rats

Authors

  • Satrasala Neelima Department of Pharmacology, Vasavi Institute of Pharmaceutical Sciences, Vasavi Nagar, Peddapalli (Village), Sidhout (Mandal), Kadapa (Dist)-516247, Andhra Pradesh, India https://orcid.org/0000-0002-2195-0238
  • Pradeep Kumar M Department of Pharmaceutical Technology, Vasavi Institute of Pharmaceutical Sciences, Vasavi Nagar, Peddapalli (Village), Sidhout (Mandal), Kadapa (Dist)-516247, Andhra Pradesh, India https://orcid.org/0000-0003-3555-249X
  • Bandi Mounika Department of Pharmacology, Oil Technological & Pharmaceutical Research Institute (OTPRI), Sangameswar Circle, Ashok Nagar, Anantapur-515001, Andhra Pradesh, India

DOI:

https://doi.org/10.26452/fjphs.v2i4.312

Abstract

The goal of the current research was to examine the potential for Glycyrrhiza glabra L., (a member of the Fabaceae family) root extract to treat wounds. Using excision and burn wound models, the ethanolic root extract of Glycyrrhiza glabra was assessed for its wound healing efficacy in rats. When compared to the control group, which had a wound area of 28%, the extract-treated animals showed reductions in the wound area of 73% and 92%, respectively (5% and 10%w/w). In the excision model, it was discovered that extract-treated wounds epithelialized more quickly and contracted at a higher rate than control wounds. Histopathological research provided additional proof of this. Studies on wound contractions found that as the concentration of herbal extracts rises, so do the wound contractions. Both types come preinstalled with mupirocin. In diabetic rats, Glycyrrhiza glabra significantly speeds up wound healing; additional research into this effect in people is advised.

Keywords:

Glycyrrhiza glabra L., Wound Healing, Cell Proliferation, Inflammatory Cytokines, Epithelization

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Published

2022-09-14

How to Cite

Satrasala Neelima, Pradeep Kumar M, & Bandi Mounika. (2022). Wound Healing Potential of Ethanolic Extract of Roots of Glycyrrhiza glabra L. in Diabetes Induced Rats. Future Journal of Pharmaceuticals and Health Sciences, 2(4), 269–275. https://doi.org/10.26452/fjphs.v2i4.312

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Original Articles