In vitro anti-proliferative activity of newly synthesized compounds of substituted-(3-phenyl-1,2,4-oxadiazol-5yl)-methyl-9-chloro-2,3-dimethyl-6,7-dihydro-5H-benzocyclohepten-8-carboxylates

Abstract

A series of the newly synthesized substituted-(3-phenyl-1,2,4-oxadiazol-5yl)-methyl-9-chloro-2,3-dimethyl-6,7-dihydro-5H-benzocyclohepten-8-carboxylates 13a-h have been assessed for their anti-proliferative activity in vitro and shown negative effect with GI₅₀ values 0.320-4.750 µM towards cancer cell growth. The compounds 13d, 13e, 13f, 13g showed significant activity towards three cancer cell lines of human. Among them 13 gm showed strong anti-cancer activity towards PANC-1 at 0.312 mM respectively. Notably, compound 13e showed significant activity at 0.320 mM against MDA MB-231 respectively.