Formulation and Evaluation of Cimetidine In-Situ Gelling System By Factorial Design

Abstract

The current papers offer the formulation, optimization, and evaluation of the starch-based in-situ gelling system of Cimetidine. The objective of the present study was to optimize the concentration of starch and concentration of MgCl₂ for the formulation of in-situ gels of Cimetidine. Starch based in-situ gels of Cimetidine were subjected to measurement of viscosity, pH, drug content, and Q₈₀. Entirely the preliminary batches were prepared by using different concentrations of sodium alginate (0.5% - 2%) and a constant concentration of MgCl₂. On source the preliminary Screening, a 3² full factorial pattern set about to review the consequence containing self-sustaining variables, Put concentration Containing starch (X₁) and concentration containing MgCl₂ (X₂) as to apprenticed probabilities like viscosity, drug content, Q_80, and similarity factor. The best formulation C9 exhibited optimum viscosity (316 cp), drug content (99.25%), Q₈₀ (90.15%), and similarity factor (73.46). The best batch exhibited good water uptake (62.44%) and there were no interactions were found during the IR study. A slow release of Cimetidine was observed and a good fit to the Korsmeyer Peppas plots was demonstrated. The correlation coefficient of the best batch is 0.9973 (Korsmeyer Peppas plots).