Development and Characterization of Quercetin Loaded Polycaprolactone Nanoparticles for Tumors

Abstract

Cancer is one of the dreadful diseases in the world, with a poor prognosis. Numerous assessments showed both tissue and cell distribution profiles of anticancer drugs might be reliant their defense in submicronic nanoparticles. The explanation behind this way is to wage increase antitumor efficacy while lowering systemic unwanted effects. These nanoparticles are well known to show theranostic activity which further increases the therapeutic index. In this study, we are developing antioxidant quercetin for the anti-tumor effect. The quercetin nanoparticles are prepared using the nanoprecipitation method with polycaprolactone as a polymer in which the nanoparticles are recovered. These nanoparticles are further optimized for the drug loading, characterized by the morphology using SEM and drug-polymer interactions by FT-IR, DSC. This lipophilic drug has shown a maximum entrapment efficiency of 81% and the SEM images showed nanoparticles of different shapes. There showed no interactions indicating the stability of quercetin-loaded polycaprolactone nanoparticles.