Cross-linked Polymeric Aceclofenac Hydrogels Formulation and Characterization

Abstract

Hydrogels are cross-linked polymeric networks that may store water within the gaps between the polymeric chains. Drug delivery, cell carriers and/or trapping, wound treatment, and tissue engineering is just a few of the biomedical applications that have made substantial use of hydrogels. Aceclofenac hydrogels were created employing polymers such as HPMC, sodium alginate, and Eudragit RL100 either through the physical cross-linking approach orionotropic gelation process. Aceclofenac hydrogels were tested for bulk density, tapped density, percentage yield, swelling ratio, and water uptake. In all formulations, the results in bulk density, tapped density, and percentage yield were quite excellent. All created formulations were subjected to in-vitro drug release tests in order to determine the drug release pattern, and the in-vitro release data were treated to several kinetic models. The correlation coefficient values (R=0.999644) show that the drug release kinetics were zero order. Peppa's model determined the mechanism of drug release, which shows super-case II transport as demonstrated by diffusion exponent values (n =0.949948). As a result, Aceclofenac may be a good candidate for hydrogel production.