A Case Study on Exercise-Induced Acute Kidney Injury

Abstract

Hypouricemia is a condition which refers to hyper-uric acid clearance due to a defect in renal tubular transport. It is considered as a hereditary renal problem. Patients with hereditary renal hypouricemia have a higher risk of exercise-induced acute kidney injury and reduced kidney function. Although avoiding  exercise is considered as the best preventive measure, there are many kinds of jobs that require occupational exercise. A 32-year-old male physical trainer suffered from stage 3 Acute Kidney Injury after performing a 18-m multistage shuttle run test. His father had previously been diagnosed as having renal  hypouricemia at another facility. The patient had reported having hypouricemia during a health check, but his serum uric acid concentration was within the  normal range at our hospital. After treatment, he recovered from exercise-induced acute kidney injury and exhibited low serum uric acid and hyper-uric acid  clearance. Since the patient desired to continue his career requiring strenuous exercise, it was difficult to propose a preventive plan against the recurrence of  exercise-induced acute kidney injury. Patients suffering with hereditary renal hypouricemia are at higher risk of developing Acute Kidney Injury when undergo  strenuous occupational anaerobic exercise than other workers. Hence the risks of exercise-induced acute kidney injury among patients with hypouricemia  should be considered when undergoing physical occupational training.