Extraction, characterisation and evaluation of curcumin gel

Abstract

This paper describes the formulation and evaluation of transdermal gels for topical delivery of Curcumin. A polymer with well-defined transdermal characteristics, such as Carbopol 934, was used in this investigation. Using a variety of absorption enhancers, including Mannitol, sodium lauryl sulfate, and polyethylene glycol, carbopol, HPMC gels containing 1% curcumin were prepared using a cold technique. Due to its poor bioavailability, Curcumin has been produced in a gel form with sodium lauryl sulfate, mannitol, and polyethylene glycol as absorption enhancers. The gels underwent investigation concerning gelation temperature, pH, viscosity, drug release profile, drug content, stability studies, and kinetic analysis of drug release data. Because sodium lauryl sulfate shows a higher percentage of drug release than other absorption enhancers, it was determined to be a better enhancer of absorption.