Formulation and evaluation of nifedipine fast dissolving tablets

Abstract

The current study aims to formulate and evaluate the fast-dissolving tablet. The optimal concentration of Guar gum super disintegrate was found to be 20 mg, with a disintegration time of 27 seconds. This study assessed the disintegration time of tablets containing natural super disintegrant for the Disintegration test at various weight concentrations (6,8,10,12,14,16,18, and 20 mg). As a result, the Nifedipine fast dissolving tablets with Guar gum super disintegrant provide a quick therapeutic effect, a high dissolve rate, and a shorter disintegration time. In this study, the use of a natural (guar gum) super disintegrating agent increases the rate of dissolution as well as length of disintegration of fast-dissolving tablets. In vitro drug release of 96% is demonstrated in 6 minutes with a disintegrating efficiency of 27 seconds for Nifedipine FDTs (guar gum). Consequently, our study has shown that formulations made with a natural super disintegrating agent exhibit shorter disintegration times as well as higher rates of dissolution along with drug release.