Formulation and Evaluation of Miconazole Nanocapsules

Abstract

Using the emulsion solvent diffusion technique, the current study's goal was to create and analyze miconazole nanocapsules. Ethyl cellulose as well as HPMC nanocapsules were used to fill the miconazole, which has been produced using the emulsion solvent diffusion method. The FTIR data showed that the miconazole nanocapsules filled with ethyl cellulose nanocapsules were stable and that there was no drug-polymer interaction. To determine whether there is no incompatibility in the formulation, compatibility investigations like FTIR & DSC were utilized. The morphological particle size of miconazole nanocapsules is assessed using SEM. This complete formulation codes for the nanocapsules were F1 to F8. The optimum formulation F6's in vitro dissolution rate was found to be 75.22 percent. A variety of mathematical models, including the zero order, first order, Higuchi matrix, and Korsmeyer peppas model, were fitted to the data on drug dissolution in vitro. The model that the miconazole nanocapsules use has R2 values of 0.937, 0.399, 0.899, and 0.785 and m values of 1593, 0.061, 11409, and 2.560. The Nanocapsules released the medication over 45 minutes. The ethyl cellulose and HPMC nanocapsules that contain miconazole were created under ideal circumstances and exhibit good release properties.