A review on calcinosis cutis

Abstract

Calcinosis, marked by hydroxyapatite, calcium, and phosphate deposits in skin and subcutaneous tissues, is common in individuals with various physiological conditions, soft tissue ailments, and autoimmune disorders. Researchers categorize and analyze these occurrences, shedding light on their pathophysiology. They also review scientific evidence regarding non- pharmacologic and pharmacodynamic treatments. Calcinosis cutis involves the accumulation of insoluble calcium ions in the epidermis and subcutaneous tissue, classified into dystrophic, metastatic, idiopathic, iatrogenic, and calciphylaxis subgroups. Dysplastic deposits result from cellular damage, while metastatic calcification stems from irregular potassium and phosphorous metabolism. Undiagnosed calcification occurs independently of tissue destruction or underlying disease. Autoimmune syndrome-induced epidermal calcification is a rare therapy-related effect. Calciphylaxis, primarily affecting the vascular system, is introduced, with disturbances in calcium and phosphorus biotransformation and congenital hypothyroidism as contributing factors.