Pharmacognostic and Phytochemical Analysis of Oxalis Latifolia Kunth and their Antiulcer Activity in Albino Rats

Abstract

In a rat model of stomach ulceration caused by Pylorus ligation and Indomethacin, the purpose of the current study was to assess the pharmacognostic, phytochemical analysis, and antiulcer potential of Oxalis latifoliaKunth (OL). The entire OL plant was gathered, dried, and powdered, and its macroscopic and microscopic properties were evaluated. To test for good yield and phytochemical components, powdered OL was extracted using a variety of solvents. Methylated as methanolic Oxalis latifolia Kunth (MEOL) was chosen for isolation because it had a high yield and quantity of components. Latifolin A, the active chemical, was isolated from MEOL and subjected to IR, NMR, and mass spectroscopy analysis. Later, Latifolin A was developed as 5 mg/kg capsules and tested for several parameters. Following ulcer induction, a number of measures including gastric acid secretion volume, pH, total acidity, ulcer index, and antioxidant parameters were measured and compared between animals in the negative control, formulation, extract-treated, and standard group. According to the findings of this investigation, Oxalis latifoliaKunth's methanolic extract has a fair yield and a high concentration of phytoconstituents. Latifolia A, a flavonoid component of the extract, is found in luteolin-6??-(E-p- hydroxycinnamoyl) 4?-O-D-glucopyranoside, which is extracted, evaluated using several spectrum techniques, and then packaged as a capsule. In comparison to MEOL alone, formulation of Latifolia A shown good antiulcer properties in both animals. This could be as a result of other Latifolia A capsule ingredients not interfering. Standard drug is Ranitidine (100mg/kg). Latifolia A is mainly responsible for the antiulcer activity in Pylorus ligation and Indomethacin induced gastric ulcer model in rats.