Effectiveness of Oral Hypoglycaemics in Type-2 Diabetes Mellitus Patients at a Tertiary Care Hospital : A Comparative Observational Study

Abstract

Hyperglycemia, or a state of high blood sugar, is a symptom of diabetes mellitus (D.M.), a complicated chronic disease brought on by deficits in insulin production, activity, or both. Since type 2 diabetes mellitus is a frequent and spreading condition, it is a significant global public health issue. The International Diabetes Federation estimates that 629 million people will have diabetes by 2045, up from the current 425 million cases. The main objective is to compare the effectiveness of oral hypoglycaemics in Type-2 Diabetes Mellitus patients at a tertiary care hospital. This prospective observational study was carry out for six months at HKES’s Basaveshwar Teaching and General Hospital, Kalaburagi. Patients were enrolled based on eligibility criteria. Study populations of 120 subjects with incident Type 2 Diabetes Mellitus were enrolled. Among 120 issues, 25 (20.83%), 15 (12.5%), and 20 (16.66%) subjects are under the treatment of Biguanides, Sulfonylureas, and DPP-4 Inhibitors. 10 (8.33%), 30 (25%) and 20 (16.66%) subjects are under the treatment of Biguanides and Sulfonylureas combination, Biguanides and DPP-4 Inhibitors combination and Biguanides, Sulfonylureas and DPP-4 Inhibitors combination. Finally, conclude that the DPP4  Inhibitor combination group of drugs  is better than other anti-diabetic medications in maintaining good glycemic status in type 2 D.M. patients, particularly Biguanides+DPP-4 Inhibitors and then followed by Biguanides+DPP-4 Inhibitors + Sulfonylureas by comparing all the laboratory values obtained.