Formulation and evaluation of transdermal delivery of beclomethasone dipropionate via ethosomes

Abstract

This study tested beclomethasone dipropionate for maximal solubility in aqueous buffers to formulate and evaluate beclomethasone dipropionate ethosomes for transdermal delivery. Compared to traditional liposomes, ethosomal systems can deliver greater concentrations of beclomethasone dipropionate via mice's skin at a regulated release rate. Ethosomal formulations had much greater drug flow values (P G.01). This would suggest that ethanol improves the way drugs pass through the layers of the skin. Of all the generated ethosomal formulations, 22.83 ± 0.56 ?g/cm2/h was the most significant drug flow obtained. The release kinetics mechanism was assessed by fitting the permeation data to the zero-order, first-order, and Higuchi diffusion models. A linear link between the quantity of drug released and the square root of time was discovered, and all permeation profiles followed the Higuchi diffusion model. The primary barrier to drug penetration is bypassed when the medication is transported by ethosomes into the stratum corneum, greatly enhancing skin delivery. However, the amount that this function enhances transdermal flux may depend on several variables, including medication release from vesicles in the stratum corneum.