International Journal of Clinical Pharmacokinetics and Medical Sciences

Formulation and characterization of capecitabine muco adhesive beads for the treatment of colorectal cancer

2025-01-17T13:40:09+0530

This study focuses on the formulation and characterisation of Capecitabine muco-adhesive beads for the treatment of colorectal cancer. The alginate beads were synthesised using the ionotropic external gelation technique. To maximise encapsulation efficiency and control the release of Capecitabine from the alginate beads, precise formulation conditions were implemented. Results from in vitro dissolution studies revealed that formulations incorporating increasing concentrations of sodium alginate with SCMC released the drug more rapidly compared to those formulated with sodium alginate and HPMC. Moreover, beads prepared using a 2% w/v aluminum chloride solution as the gelling agent demonstrated greater rigidity compared to those formed with a 2% w/v calcium chloride solution. This highlights the importance of selecting an appropriate gelling agent to optimise bead structure and functionality. Further research is necessary to develop the most effective formulations of Capecitabine for improved therapeutic outcomes in colorectal cancer treatment.

Formulation and evaluation of transdermal delivery of beclomethasone dipropionate via ethosomes

2025-01-17T13:59:18+0530

This study tested beclomethasone dipropionate for maximal solubility in aqueous buffers to formulate and evaluate beclomethasone dipropionate ethosomes for transdermal delivery. Compared to traditional liposomes, ethosomal systems can deliver greater concentrations of beclomethasone dipropionate via mice's skin at a regulated release rate. Ethosomal formulations had much greater drug flow values (P G.01). This would suggest that ethanol improves the way drugs pass through the layers of the skin. Of all the generated ethosomal formulations, 22.83 ± 0.56 ?g/cm2/h was the most significant drug flow obtained. The release kinetics mechanism was assessed by fitting the permeation data to the zero-order, first-order, and Higuchi diffusion models. A linear link between the quantity of drug released and the square root of time was discovered, and all permeation profiles followed the Higuchi diffusion model. The primary barrier to drug penetration is bypassed when the medication is transported by ethosomes into the stratum corneum, greatly enhancing skin delivery. However, the amount that this function enhances transdermal flux may depend on several variables, including medication release from vesicles in the stratum corneum.

Microneedles in transdermal drug delivery system

2025-01-25T15:30:27+0530

One such review paper focuses on Minnesota's advanced technologies, highlighting the latest updates on drug delivery methods, challenges, and innovations. Intravenous therapy, a non-invasive and pain-free approach, is often used for drug delivery. This method offers a complete bioactivity with minimal intrusion, enabling the administration of medication through the skin. The effectiveness of this treatment is influenced not only by the transdermal delivery system but also by profiling, which helps optimize the release of active ingredients.The paper discusses various components of intravenous therapy and fabrication techniques, emphasizing their role in managing drug release. For instance, therapies can be administered directly into the epidermis and uveitis area, regulating the release of therapeutic substances over a specific time frame. Several delivery systems, such as polypropylene and nanogels, have been explored for their ability to extend the delivery of active components, improving therapeutic outcomes.Additionally, the review highlights the application of these technologies in treating various medical conditions. Researchers also examine the design requirements for efficient drug delivery systems, including material choice and machine learning simulations to optimize performance. Needle-free methods have been proposed to bypass the skin's lipid barrier, enabling effective nutrient delivery. New technologies in Minneapolis also show promise for conditions such as insulin administration, subcutaneous injections, and gene transfer, demonstrating significant progress in non-invasive healthcare solutions.