International Journal of Clinical Pharmacokinetics and Medical Sciences

A cross-sectional study of knowledge and barriers in uptake of cervical cancer screening

2024-07-29T19:17:14+0530

More than 90% of instances of cervical cancer in women occur in developing nations, making it the second most frequent malignancy in women globally. About 15% of cancer-related fatalities worldwide are attributed to India, primarily in rural regions. This harmful condition can be effectively prevented by developing awareness campaigns and offering early Screening as a viable management option. From January 1, 2024, to June 30, 2024, a prospective questionnaire-based survey was carried out among women. Students made up the majority of the research population. There were 340 ladies among them. The majority of the 292 women (86%) who have not attended Screening gave a variety of excuses. Of the 48 women who showed up for the test, 23 (or 47.9%) had different symptoms and were receiving treatment. Three of these individuals were found to have cervical cancer. Obstacles were noted, including a weak economy, cultural legacies, ignorance, a shortage of women in the testing facilities, etc. Pap smear testing facilities must be available to all medical professionals and primary healthcare facilities.

Evaluation and investigation of micellar structure of pluronic copolymer nanoaggregates of Docetaxel

2024-07-05T21:59:37+0530

The study was undertaken to develop and characterize docetaxel-loaded lyophilized block co-polymeric micelles for cancer therapy treatment. The study demonstrates that micellar size, shape, zeta potential, and other characteristics of lyophilized polymeric micelles are appropriate; furthermore, because of the polymer's encapsulation and capacity to maintain the drug release, significantly reduces toxicity and adverse effects. Block co-polymeric micelles offer improved solubility and a high capacity for drug loading, perhaps enhancing the bioavailability. As per this research, the idea of employing block co-polymeric micelles to enhance the solubility of hydrophobic medications holds excellent promise as an intravenous drug delivery system. While the outcomes are encouraging, the docetaxel-loaded block co-polymeric micelles must be further evaluated for In-Vivo studies to check the targeted drug delivery.Bottom of Form

A CROSS-SECTIONAL CLINICOMYCOLOGICAL STUDY OF TINEA CORPORIS IN AN INDIAN TERTIARY CARE HOSPITAL

2024-09-10T16:24:07+0530

Tinea corporis, a fungal infection of the skin, hair, and nails, has become a significant public health concern in recent years. This study aimed to assess the frequency of various fungal species associated with Tinea corporis and explore potential correlations with clinical features. A total of 311 cases from a tertiary care facility in India participated in this cross-sectional study. Samples from skin, hair, and nails were analyzed using fungal cultures and potassium hydroxide (KOH) mounts. Most patients were male and in their third decade of life, with 13% having Tinea corporis et cruris and 48.8% reporting a positive family history. Trichophyton mentagrophytes was the most commonly isolated species (80.92%), followed by Trichophyton rubrum (14.54%). No significant correlation was found between clinical characteristics, such as body surface area or illness duration, and the type of fungus identified.

A new sensitive and robust method development for estimation of tolcapone and quinapril in the bulk and formulations

2024-07-22T21:57:29+0530

Tolcopone and Quinapril are anti-hypersensitive drugs and, in combined dosages, are effective in managing hypertension. The RP-HPLC method was developed using OPA and Acetonitrile in 50:50 v/v as Mobile phase and 250*4.6mm, 5µ RP-HPLC column measured with a wavelength of 240nm. The HPLC system was fixed with a flow rate of 1.0ml/min; Both drugs, TOLCO and QUINA, were successfully detected at 2.153 and 3.203 min, respectively. The validation of the method as per ICH Linearity r² lies at 0.999, and Precision, system suitability, and selectivity RSD values are within permissible limits. The accuracy of the process was found to be 99.73 and 99.52 for TOLCO and QUINA, respectively. The LOD 0.72 and 0.3 µl/ml and LOQ 0.84 and 0.13 µl/ml. The robustness and degradation studies show that the selected method is acceptable per the Guidelines.Bottom of Form