Evaluation and investigation of micellar structure of pluronic copolymer nanoaggregates of Docetaxel

Abstract

The study was undertaken to develop and characterize docetaxel-loaded lyophilized block co-polymeric micelles for cancer therapy treatment. The study demonstrates that micellar size, shape, zeta potential, and other characteristics of lyophilized polymeric micelles are appropriate; furthermore, because of the polymer's encapsulation and capacity to maintain the drug release, significantly reduces toxicity and adverse effects. Block co-polymeric micelles offer improved solubility and a high capacity for drug loading, perhaps enhancing the bioavailability. As per this research, the idea of employing block co-polymeric micelles to enhance the solubility of hydrophobic medications holds excellent promise as an intravenous drug delivery system. While the outcomes are encouraging, the docetaxel-loaded block co-polymeric micelles must be further evaluated for In-Vivo studies to check the targeted drug delivery.Bottom of Form