Formulation and Evaluation of Voriconazole Loaded Nanosponges for Topical Delivery

Abstract

In this research, Voriconazole was first formed into a gel form, and then nanosponges were made using the solvent evaporation approach. By combining PVA into a co-polymer as well as HP-cyclodextrin and even HPMC K4M as rate-retarding polymers, the formulations for Nanosponges were produced. The compatibility of the medicine with formulation ingredients has been evaluated using Fourier Transform Infra-Red (FTIR) spectroscopy. We examined the surface morphology, yield, and drug entrapment effectiveness of the Nanosponges. SEM analysis was used to investigate the Nanosponges' shape and surface morphology. Nanosponges were discovered to be porous and spherical by scanning electron microscopy. SEM images showed that the Nanosponges were spherical in all configurations; however, at larger ratios, drug crystals were seen across the nanosponge surface. Improvement within the drug/polymer ratio (1:1 to 1:3), which takes place in ascending sequence due to the rise in polymer concentration, however after a certain level of concentration, it was noted that when the drug/polymer ratio rose, the particle size declined. All formulations' average particle sizes fall between 316.4 and 454.8 nanometers. The drug release of the optimised formulation was found to be 99.42%, while the drug content of other formulations ranged from 82.8 to 97.2% and their entrapment efficiencies from 86.24 to 96.88%. The optimised gel formulation's stability studies show that the formulated gel was stable up to 90 days.