Evaluation of Dose Adjustment of Antibiotics in Renal Impaired Patients in a Tertiary Care Hospital
DOI:
https://doi.org/10.26452/ijcpms.v2i4.443Keywords:
Adverse effects, Antibiotics, Dose adjustment, Renal impairmentAbstract
Patients having renal impairment may have altered excretion of antibiotics and their metabolites leading to its excessive accumulation in the body. These patients are more prone to adverse effects and other complications and, in some cases, may even lead to fatality. Dose adjustment of antibiotics is necessary to avoid these effects. This study aims to evaluate the dosage adjustments of antibiotics in renal impaired patients. This is a prospective observational study performed in the department of nephrology at Malla Reddy Narayana multi-speciality hospital on 100 subjects who were selected based on inclusion and exclusion criteria. Statistical clarification was done to decode the unbiased analysis and final conclusions were drawn. According to the study findings, 72% of the antibiotics prescribed were adjusted and the rest 28% were unadjusted. Amoxicillin clavulanate was found to be the most unadjusted antibiotic followed by meropenem, ciprofloxacin and ceftriaxone. 5 ADRs because of unadjusted antibiotic doses were observed. Understanding the need for dose adjustment in renal impaired patients will help reduce the dosing errors in such patients. Lack of dose adjustment of antibiotics can lead to life-threatening complications and even morbidity and mortality. Hence, the role of the clinical pharmacist is important in understanding the need for dose adjustment to optimize therapeutic efficacy and minimize toxicity.
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