Development of Aceclofenac Solid Self-Emulsifying Drug Delivery Systems

Abstract

Aceclofenac is NSAIDs used for the diagnosis of analgesic, antipyretic, rheumatoid arthritis, gout. The solubility of Aceclofenac was 50mg/ml in water. Because of poor aqueous solubility drug has low oral bioavailability (50-60%). Within present research one effort was made to create the SMEDDS of Aceclofenac which increases the solubility and bioavailability of drug. Twenty seven formulations of liquid SMEDDS were formulated with different concentrations of oleic acid, Chremophore RH 40 and PEG 400. The surfactant and co-surfactant mixture (S_mix) ratio has been selected based upon the self emulsification region found in Pseudo ternary phase diagram. Among different ratios of S_mix i.e., F1 (1:1), F2 (1:2), F3 (2:1), formulations 1:2 ratio of S_mix was selected to prepare Liquid SMEDDS. Among three formulations S1 is showing good results and in-vitro drug release studies are showing more liner and highest percentage release of drug of 98.15 at the end of 60min. Drug release mechanism was found to be zero-order based on the results of various kinetic models.