Assessing the Patterns and Occurrence of Adverse Drug Reactions in a Tertiary Care Hospital: An Observational Study

Abstract

For more than a decade, adverse medication responses have been a significant problem in healthcare. It is the obligation of healthcare providers to use rational drugs for their patients. The study's goal was to find out how often ADRs are in a tertiary care hospital, as well as the most common Therapeutic Class of Drugs that cause ADR and the most common Organ System impacted by ADR. Between January and August 2016, a prospective, observational study was done in the wards of St. Philomena's Hospital in Bangalore. During their admission, all in-patients were checked for ADRs. A total of 274 adverse drug reactions (ADRs) were documented in 700 individuals during the course of the 12-month research. Female patients had more ADRs than male patients (52.9 percent). The majority of the reactions were gastrointestinal (70%) and fluid and electrolyte imbalance (48%) respectively (17.51 percent). Antibiotics were the most commonly related therapeutic classes with ADRs, accounting for 84 percent (30.65 percent), followed by antihypertensive medicines, accounting for 63 percent (22.99 percent). The majority of ADRs (34.67 percent) were dealt with by stopping the implicated drug. The Naranjo's Scale algorithm was used to analyse the causation of the ADRs, and the majority of them were determined to be probable 133. (48.5percent). In a hospital setting, continuous monitoring by a clinical pharmacist will reduce the occurrence of ADR and increase patient safety.