Formulation and evaluation of bioadhesive suppository dosage form

Abstract

The current study aims to formulate and evaluate a dosage form for bio-adhesive suppositories. Using CB and HPKS (CE and SS) as suppository bases, optimized manufacturing techniques successfully made suppositories containing bio-adhesive polymers (CBP, PVP, HPMC, and CMCTS). Analyzing dosage forms is crucial to determining the quality of a product. The suppositories produced in this investigation had good weight consistency, with minimal variation (±1%) between the goal and actual weight. All formulations showed melting values between 32.5 and 35.5 degrees Celsius, while the melting points of suppositories made with CE and SS were 1-2 degrees Celsius greater than those of CB suppositories. Incorporating bio-adhesive polymers did not cause a substantial change in the suppositories' melting point (less than ± 1 °C), keeping it around body temperature and appropriate for rectal administration. More than 95% of the required DcNa content was present in every formulation tested. All formulations, however, had softening durations of three to seven minutes, which was suitable for rectal medication delivery. The physical characteristics of the suppositories this chapter looked at were determined to be appropriate for administration by the rectal route. Compared to CB suppositories, HPKS suppositories have an additional benefit due to their longer softening time and melting point of 34.5 ± 1 °C.