Formulation and evaluation of irbesartan fast disintegrating tablets by direct compression technique

Abstract

The main objective of the present study is to develop a pharmaceutically stable, cost effective & quality improved robust formulation. The main aim of the present work is to formulate & evaluate Irbesartan fast disintegrating tablets by using pH 6.8 phosphate buffer as a dissolution medium, USP II paddle method. The superdisintegrants sodium starch glycolate, croscarmellose sodium, and crospovidone were used in the current work to generate a total of six distinct formulations employing the direct compression method. Irbesartan, an angiotensin receptor blocker, has a role in the treatment of hypertension. This review summarises recent developments in this area and looks at the role of this drug in light of studies that assessed its safety, tolerability, as well as effectiveness. The prepared batches were evaluated for disintegration and  In vitro dissolution studies. Among all the formulations, F3 was concluded to be the best formulation, because it is having the disintegration time of less than 3 mins and showed 95% dissolution within 30mins.