Lissencephaly with CMV Infection: A Case Study

Abstract

A nine months old baby boy was admitted in a pediatric ward at SGG Hospital, Vadodara diagnosed with lissencephaly associated with Cytomegalo virus (CMV) infection. Lissencephaly includes severe brain deformations. Cytomegaly infection is popularly known as a pathogen for this anomaly. He had both Computer Tomography scan and Magnetic Resonance Imaging tests. A social smile was absent and he was previously diagnosed with Global Developmental Delay (GDD) and a deformed head. Congenital Cytomegalo infection (CMV) is a vertically transmitted disease in newborn infants which causes multiorgan affection. But the most severe and permanent damages are those affecting the central nervous system (CNS) such as mental retardation, sensorineural hearing loss, chorioretinitis, cerebral palsy, and seizures as a result of the virus with neurogenesis.