A Case Report On Type- II Lepra Reaction

Abstract

Lepra reactions remain a significant persistent problem in leprosy. Type 1 and type 2 (erythema nodosum leprosum-ENL) reactions are main cause of nerve damage and permanent disabilities. Type 1 reaction is associated with cellular immunity whereas Type 2 reaction (ENL) is related with humoral immunity and explicitly type 1 reaction is due to the reaction of T helper 1 cells against mycobacterial antigens and type 2 reaction is specified by systemic manifestations along with novel erythematous subcutaneous nodules. Proper diagnosis of lepra reactions is important for timely institution of therapy and to treat disability and morbidity. In this case the patient primarily presented with the symptoms of fever and fatigue along with superficial lesions on hands and face. Abrupt alterations in immune-mediated reaction to mycobacterium leprae antigen are called as lepra reactions.