The Nephroprotective Activity of Elephantopus scaber Linn Roots, Leaves, and Flowers on Gentamicin Induced Nephrotoxicity

Abstract

The goal of the current investigation was to determine whether an ethanolic extract of Elephantopus scaber had nephroprotective properties. Animals into five groups, including Group I control, Group ii negative control, that also started to receive Gentamicin 100mg/kg B.W., i. p, O. D. For 12 days, For 12 days, Group iii began to receive a kind Elephantopus scaber extract of the roots. Group IV received a section of the flowers. Group III received an Elephantopus scaber extract of the sources, and Group IV received an Elephantopus scaber extract of the flowers. Gentamicin 100mg/kg, i.p., O.D. plus Elephantopus scaber leaf extract, 100mg/kg B.W., was administered to Group V for 12 days. It also tested the in vitro antioxidant and free radical scavenging operations of various extracts Nephrotoxicity associated with gentamicin. Overall study findings indicated that Elephantopus scaber root extract successfully prevents kidney damage brought on besides gentamicin-induced Nephrotoxicity while also going to lower physiochemical urinary but also serum marker enzymatic as though creatinine, urea, but also uric acid. In gentamicin-treated animals, the kidney histopathology examinations found that Elephantopus scaber root extract had a protective effect. The findings showed that pretreatment with an ethanolic extract of Elephantopus scaber roots might help avoid kidney injury in experimental mice caused by gentamicin.