Formulations and evaluations of repaglinide microspheres by ionotropic gelation technique

Abstract

The current study aimed to formulate and evaluate Repaglinide microspheres utilizing the ionotropic gelation process, with sodium alginate, HPMC, and Carbopol as polymers and Cacl2 as a cross-linking agent. Because of its high biocompatibility and lack of toxicity, sodium alginate is a biodegradable natural polymer with considerable promise for therapeutic uses. Repaglinide microspheres offer desirable qualities. The ionotropic gelation approach allows for high medication integration in microspheres without harmful agents that have adverse side effects. The microspheres are tested for percentage yield, entrapment efficiency, micromimetic properties, in-vitro drug release, etc. Extensive in-vitro testing revealed that more than 102% of the medication is released after 11-12 hours; however, in this formulation, drug release is maintained for up to 12 hours. The percentage entrapment efficiency is 102%. The microspheres had a percentage yield of 96%. Using essential equipment, ionotropic gelation can also be carried out under relatively mild situations. Managing numerous manufacturing parameters is critical in producing microspheres with superior sphericity, high yield, and exceptional drug encapsulation.