Perioperative Antibiotic Prophylaxis in a Tertiary Care Hospital: An Observational Study

Abstract

A Retrospective study was conducted for 6 months in a 650 bedded tertiary teaching hospital involving in-patients of the general surgery department. During the research period, 102 participants' data was collected in a specified format from medical case records and drug charts. The acquired data was subjected to descriptive statistics and analysed using Microsoft Excel software. This study involved 57% females and 43 % males. The general surgery department (57%) contributed to most of the cases in our study. The most common surgeries performed were Hernia repair (12.7%) and Septoplasty (12.7%). Preoperative antibiotic prophylaxis was prescribed for 87 (85.2%) subjects. To them Inj. Cefotaxime IV was the most prescribed and 1gm dose was commonly prescribed in 42% of the participants pre-operatively and 51% of the participants post-operatively. In the case of a combination of antibiotic usage, it had been found that preoperatively. In 23% of the samples, Ceftriaxone+Metronidazole was the most often recommended combination. After surgery In 35% of individuals, cefotaxime+metronidazole was the most usually given combination. Overall compliance with prophylactic antibiotics was following the guidelines of NCDC version 1.0 (2016). The guidelines insisted to prescribe Cefazolin, Ceftriaxone instead of Cefotaxime. The density of antimicrobial use for postoperative antimicrobial prophylaxis was very high. Institutional antibiotic recommendations might be more beneficial, resulting in more acceptability and compliance. Furthermore, active participation and provision of cooperating multidisciplinary teams, which include clinical pharmacists, dispensing pharmacists, and management, can aid in programme quality enhancement.