International Journal of Clinical Pharmacokinetics and Medical Sciences
https://pharmasprings.com/ijcpms
<div> <img style="width: 100%;" src="https://pharmasprings.com/templates/frontend/pages/slideshow/slideshow2.gif" /></div> <p align="justify">International Journal of Clinical Pharmacokinetics and Medical Sciences <em>(IJCPMS)</em> ISSN: 2583-0953 is established in the year 2021 officially sponsored by <em><strong>pharma springs publication</strong></em>. We are pleased to introduce ourselves as the novel imminent, and sovereign online pharmacy & medical information services in India. The foundation aims to serve as a means for updating the scientific knowledge of the international audience in the research field of science so a correlation can be made between these researchers. IJCPMS will be published quarterly per year in March, Jun, September, and December. The journal publishes the work that contributes significantly to further the scientific knowledge in the areas of pharmaceutical, medical & biological sciences. All contributions to the journal are rigorously refereed and are selected based on the quality and originality of the work.</p>Pharma Springs Publicationen-USInternational Journal of Clinical Pharmacokinetics and Medical Sciences2583-0953Applications of the Natural Polymers for Fast Dissolving Tablets
https://pharmasprings.com/ijcpms/article/view/584
<p>Oral route is the safest, most convenient, and economical route for administration of different drugs. Oral disintegrating tablets becoming very popular in the current scenario, as they facilely disintegrated in mouth within fewseconds of the time after its administration withoutthe need of water. Conventional dosage form has a limitations like dysphagia (arduousness in swallowing), in pediatric and geriatric patients, which have been overcome by oral disintegrating tablets. To prepare the same super disintegrating agents plays vital role. Natural Super disintegrants gained an advantage over the synthetic super disintegrants since they are chemicallyinert, non-toxic, less expensive, easily available, biodegradable in nature. Natural polymers such as locust bean gum, banana powder, pectin from mango peels, as well as the mucilageofHibiscus rosa-sinenses improve tablet qualities and are used as superdisintegrants, binder, and diluents to speed up the disintegration process as well as improve the solubilityofpoorlysoluble drugs. Natural super disintegrants are obtained from various sources of natural origin, as well as being affordable, nontoxic, biodegradable, environmentally benign, free of negative effects, as well as renewable. From the different extensive literature review, It is observed that based on research showing that natural polymersare more effectiveandsafe than synthetic ones. Thegoal ofthe current reviewpaper is to examine the natural polymersthat have FDAapproval and are used in fast dissolving tablets.</p>Nandhini MVijaya Kumar Voleti Ramesh Yamuna Anisha BashirSuganya TSindhu CKeerthika AShanmugapandiyan P
Copyright (c) 2024 International Journal of Clinical Pharmacokinetics and Medical Sciences
2024-03-072024-03-0741344010.26452/ijcpms.v4i1.584Flax seeds for human health and their benefits
https://pharmasprings.com/ijcpms/article/view/587
<p>Flaxseed (Linum Usitatissimum L) is celebrated for its abundance in Omega-3 polyunsaturated fatty acids, particularly alpha-linolenic acid, offering a myriad of health benefits. Through biochemical scrutiny, its bioactive lignans have been singled out as potentially advantageous for human health enhancement. Cultivated globally for its nutritional richness and therapeutic properties, flaxseed is utilized for both its fiber and oil content, correlating with a diminished risk of various conditions like cardiovascular disease, diabetes, cancer, osteoporosis, arthritis, and autoimmune and neurological disorders. Regular consumption has been associated with lowered blood pressure, improved lipid profiles, and enhanced insulin resistance, while its antioxidant properties promote healthier skin, faster wound healing, and alleviate menopausal symptoms such as constipation and mental fatigue. However, alongside its beneficial components, flaxseed contains compounds like phytic acid, cadmium, trypsin inhibitor, and cyclogenic glycosides (CGs), which may impede its health-promoting effects and reduce the absorption of critical nutrients. Available in three primary forms - flaxseed oil, ground flaxseed, and whole flaxseed - integrating it into one's diet could serve as a proactive measure against various health issues, underlining the plant's remarkable versatility and potential in bolstering overall well-being.</p>Vidyadhari Arava Teja Divya Mangala Divya Sree Bandi Pavani Tummala Siva Prasad Tatiparthi Ashok Kumar VRam Prathap Goud Porumamilla
Copyright (c) 2024 International Journal of Clinical Pharmacokinetics and Medical Sciences
2024-03-072024-03-0741414410.26452/ijcpms.v4i1.587Formulation and Evaluation of Phenylephrine Nasal Gels
https://pharmasprings.com/ijcpms/article/view/573
<p>The primary objective of this study is to develop and evaluate phenylephrine nasal gels, aiming for stable blood levels with lower drug doses through consistent administration, avoiding first-pass hepatic metabolism. Compatibility among the drug, polymers, and lipids was confirmed using FTIR and DSC spectra. Phenylephrine nasal gels were formulated, and their clarity assessed. The gels (ONGF1-ONGF8) had pH values of 6.1-7.2, spreadability of 18.33-21.62 g/cm/sec, and viscosity of 934.2-966.2 centipoises. Drug concentration in these formulations varied from 85.52% to 98.88%, indicating acceptable medication content. Gel strength ranged from 64% to 95%. In-vitro drug release of phenylephrine showed 77% to 95% diffusion for ONGF1. The release kinetics followed first order, zero order, Higuchi model, and Korsemeyer-Peppas equations. Kinetic values for all formulations were tabulated. ONGF1 exhibited the most efficient release, with 95% of the drug released within 7 hours, demonstrating a diffusion mechanism followed by non-Fickian transport, adhering to both zero order and Korsemeyer-Peppas models.Top of Form</p>Ameer Pasha Shaik Sowmy Adapa
Copyright (c) 2024 International Journal of Clinical Pharmacokinetics and Medical Sciences
2024-02-022024-02-024111010.26452/ijcpms.v4i1.573A prospective study on assessment of risk factors, clinical characteristics and outcomes of acute pancreatitis in a tertiary care center
https://pharmasprings.com/ijcpms/article/view/574
<p>This prospective study at RVS Hospital Chittoor targets acute pancreatitis, a severe pancreatic condition with significant health risks. Its goal is to improve patient care by analyzing risk factors, clinical features, and outcomes. Adult patients with acute pancreatitis will participate, providing comprehensive demographic, clinical, and lab data. The research will focus on key risk factors like alcohol use, gallstones, and prior pancreatitis episodes. Clinical aspects, including pain severity, systemic symptoms, and complications, will be documented, utilizing CT scans and MRI for accurate diagnosis and classification. The primary aims are identifying acute pancreatitis risk factors, understanding patient presentations, and monitoring complications during hospitalization. Secondary goals include evaluating the impact of risk factors on disease severity and mortality and exploring connections between specific risks and major complications like pancreatic necrosis and infections. This study is crucial for advancing understanding of acute pancreatitis, guiding healthcare professionals in early diagnosis, risk stratification, and effective management, ultimately enhancing patient outcomes in this complex medical issue.</p>Radhika Chikatipalli Asifa Banu Mohammad Audi Narayana Nelavala
Copyright (c) 2024 International Journal of Clinical Pharmacokinetics and Medical Sciences
2024-02-022024-02-0241111510.26452/ijcpms.v4i1.574A Prospective Study of Disease Patterns and Assessment of Drug Interactions with Prasugrel in Tertiary Care Hospital Patients
https://pharmasprings.com/ijcpms/article/view/575
<p>This prospective observational study evaluates the prescribing patterns and drug-drug interactions of Prasugrel in hospitalized patients at a tertiary care hospital (BBH). Conducted over six months, it involved 110 inpatients, gathering data from various sources including patient profiles, medicine charts, and lab tests. The study primarily focused on Prasugrel usage, identifying patient demographics and assessing the interactions of Prasugrel with other medications. It found that 64.02% of the patients on Prasugrel therapy were male and 36.08% female, predominantly aged between 55 to 75 years. These patients often had a history of cardiovascular and infectious diseases. The study revealed that 31.36% of patients experienced interactions with Prasugrel, with a higher incidence in males. The most common interactions were with Pantoprazole, Omeprazole, and Aspirin. These interactions were classified as severe (11.81%), moderate (55.05%), and mild (34.13%). Additionally, 17.91% of interactions were defined, 58.45% probable, and 22.62% possible. Prasugrel was mainly prescribed for heart disease, myocardial infarction, and angina. The study suggests cautious use of Pantoprazole with Prasugrel due to potential significant interactions.</p>Kishore BandarapalleHemanth Yadav Mopuru Mohammad Ishaqulla Kodadhavadi Saran BSree Harsha Avvaru Likhith CMujeeb Shaik
Copyright (c) 2024 International Journal of Clinical Pharmacokinetics and Medical Sciences
2024-02-022024-02-0241162510.26452/ijcpms.v4i1.575Formulation, qualitative and quantitative evaluation of hair serum using herbal ingredients
https://pharmasprings.com/ijcpms/article/view/583
<p>Combining herbs into a single composition enhances their curative and therapeutic effects compared to individual use. Even non-medicinal plants, when processed into appropriate formulations or dried powders using advanced techniques, can offer superior therapeutic benefits. Hair cosmetic formulations, particularly serums, with their high concentration of active ingredients, provide deep skin nutrition and a non-greasy finish. Integrating plants into hair serum formulations maximizes therapeutic benefits and enhances skin absorption. Herbal cosmetics, derived from botanical phytochemicals, are increasingly popular for their aromatic value and skin benefits such as suppleness, collagen protection, UV protection, and wrinkle smoothing. India's cosmetic industry is rapidly growing, with herbal cosmetics contributing significantly to revenues. Hair, being a crucial aspect of one's appearance, faces issues like dandruff, hair loss, and greying. Hair serums, with their intensive nutrition and tailored formulas, cater to diverse skin types. Overall, hair serum stands as an elegant and effective styling product, offering multiple benefits for hair and skin health.Top of Form</p>Nithya Kalyani KAbhi Sarayu Reddy PNusrathunisha SFMerlin Madhumitha JAllan Anthony JKaviarasan SShanmugapandiyan P
Copyright (c) 2024 International Journal of Clinical Pharmacokinetics and Medical Sciences
2024-03-072024-03-0741263310.26452/ijcpms.v4i1.583