Formulation and evaluation of dipotassium clorazepate topical gels

Abstract

This investigation aimed to formulate and evaluate a topical gel containing dipotassium clorazepate. To achieve the desired drug release, a topical gel containing dipotassium clorazepate was synthesized using the dispersion method. Three different gelling agents, carbopol 934p, HPMC K100, and sodium alginate, were used in four different ratios. Twelve gel formulations of dipotassium clorazepate that had been prepared were assessed for stability, drug release kinetics, drug diffusion, pH measurement, viscosity, and drug content. Drug-polymer compatibility studies were done using the Fourier Transform Infra Red (FTIR) spectrophotometer. The absence of extraneous interactions among excipients was established using FTIR. F4 released 98.53% of the drug after the eighth hour and was regarded as the best formulation. Thus, formulations containing Carbopol outperformed other formulations. Even after 6 months, the stability investigation revealed no significant change in the optimum formulation's drug content analysis or in-vitro dissolution study. The stability data were analyzed using the "Stab" software, and the anticipated shelf life term for the best formulation was 12.14 months.