Prosopagnosia: face blindness and its relationship to neurological disorders

Authors

  • Gautham Chakra R Department of Pharmacy Practice, Saastra College of Pharmaceutical Education & Research, Jwalamukhi temple, Varigonda, Totapalli Gudur mandal, near Varigonda, Nellore, Andhra Pradesh 524311 India https://orcid.org/0009-0008-6415-1840
  • Kasichetana Sri K Saastra College of Pharmaceutical Education & Research, Near Varigonda Jwalamukhi Temple, Muthukur Raod, Kakupalli, Nellore-524311, Andhra Pradesh, India
  • Aparna G Saastra College of Pharmaceutical Education & Research, Near Varigonda Jwalamukhi Temple, Muthukur Raod, Kakupalli, Nellore-524311, Andhra Pradesh, India
  • Reddy Sravani K Saastra College of Pharmaceutical Education & Research, Near Varigonda Jwalamukhi Temple, Muthukur Raod, Kakupalli, Nellore-524311, Andhra Pradesh, India
  • Mahesh Kumar Reddy V Saastra College of Pharmaceutical Education & Research, Near Varigonda Jwalamukhi Temple, Muthukur Raod, Kakupalli, Nellore-524311, Andhra Pradesh, India
  • Fayaz S Saastra College of Pharmaceutical Education & Research, Near Varigonda Jwalamukhi Temple, Muthukur Raod, Kakupalli, Nellore-524311, Andhra Pradesh, India
  • Sravan Kushal M Saastra College of Pharmaceutical Education & Research, Near Varigonda Jwalamukhi Temple, Muthukur Raod, Kakupalli, Nellore-524311, Andhra Pradesh, India

DOI:

https://doi.org/10.26452/ijebr.v3i3.633

Keywords:

Prosopagnosia, face blindness, neurodegenerative, MRI, pathology

Abstract

This study examines the neurological and neuropathological conditions, and clinical, imaging, and demographic traits linked to prosopagnosia. Out of 475 potential cases, 327 met criteria for probable or definite prosopagnosia. One patient had Niemann-Pick type C and another had a forkhead box G1 gene mutation; ten patients (80% male) had developmental prosopagnosia. Of 317 with acquired prosopagnosia, 228 had degenerative causes, primarily primary prosopagnosia syndrome, Alzheimer's disease dementia, posterior cortical atrophy, and semantic dementia. Non-degenerative cases often involved ischemic and hemorrhagic infarcts. Transient non-degenerative prosopagnosia, linked to hypoxic encephalopathy and migraines, improved over time. Degenerative prosopagnosia patients often showed temporal lobe involvement on PET scans, while non-degenerative patients had right temporal and occipital lobe lesions on MRI. Pathological findings included Alzheimer's, Lewy body disease, and frontotemporal lobar degeneration. Facial recognition loss spans various neurological illnesses.

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Published

2024-07-17

How to Cite

R, G. C., K, K. S., G, A., K, R. S., V, M. K. R., S, F., & M, S. K. (2024). Prosopagnosia: face blindness and its relationship to neurological disorders. International Journal of Experimental and Biomedical Research, 3(3), 12–28. https://doi.org/10.26452/ijebr.v3i3.633

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Section

Original Article