Evaluation of Phytolacca dodecandra stem and leaf hydroethanolic extract's in vivo anti-rabies activity

Abstract

A mouse model was utilized in the study to assess the antirabies effectiveness of a hydroethanolic extract of the stems and leaves of Phytolacca dodecandra (L' Herit) (Phytolaccaceae), one of the plants that is frequently used in Ethiopia for the traditional treatment of rabies in humans and animals. Based on the difference in the survival rate and duration (days) of the group of mice challenged with the rabies virus, the antirabies activity of both portions of the plant extract in doses of 300, 600, and 1000 mg/kg was compared with the negative control (CVS-11). The results revealed that mice's survival times were considerably reduced (P<0.05) when compared to both the positive and negative control groups, but not significantly (P>0.05) when compared to all doses of the plant's stems and 300 and 600 mg/kg dosages of its leaves. However, when compared to the mice's respective negative control group, the mice's survival duration increased significantly (P<0.05) after receiving a dose of 1000 mg/kg of the plant extract from the leaves. The discovery suggested the presence of some anti-rabies activity in P. dodecandra leaf extract at higher doses, but more research is required to clarify its active components.