Formulation and Evaluation of Terbinafine Proniosmal Gels

Abstract

The present research work of Terbinafine Proniosomal gel focuses on improving patient compliance by reducing the side effects of conventional intravenous injections and minimizing the problem of physical stability and to localize drug at site of action. The results of the study indicated that Terbinafine proniosomal gel containing lecithin, cholesterol, and surfactant Span and Tween formulations were prepared successfully using the coacervation phase separation method. The F5 formulation showed the highest efficiency. The proniosomal gel formulations were evaluated for their entrapment efficiency, drug content, UV-visible spectroscopy, viscosity, vesicle size and shape with SEM, and the results were found to be within the acceptable range. The study found that F5 has antifungal activity after 48 h, indicating that the developed proniosomal gel was more effective than the control. The results showed that F5 containing span 60 is the most appropriate surfactant for the formation of proniosomes. In-vitro release studies proved that the proniosomal gel contains terbinafine, which is considered to be a successful topical drug delivery system and provides a sustained release of the encapsulated drug. In-vitro release studies showed satisfactory results, and the permeation studies showed good control release for a prolonged period of time. Permeation studies showed the highest permeation of proniosomal gel formulation F5, and In-vitro goat skin permeation studies proved that a good amount of drug is permeated and has good stability characteristics. The study showed that the proniosomal gel formulation was quite stable at room temperature and accelerated temperature as well.