Formulation and Evaluation of Orally Disintegrating Tablets of Nimesulide

Abstract

The objective of the current study is to evolved ODT or quickly dissolving tablet preparations by direct compression method applying sodium starch as super disintegrating agent is to provide better with a maximum half-life period. The average weight of the tablets251.1 ± 0.25mg to 264.6 ± 029 mg. The hardness was determined 4.25± 0.11to 6.25± 0.17 kg/cm² during compression and for all the formulation varies from 0.47 ±0.06 to 0.30 ±0.05 %. Water absorption of all preparations was noted to be 48±1.65% to 72±1.53%. Wetting time was acknowledging to be 50±0.12 to 60±0.15 sec. The disintegration time were found to be 15±0.01 sec to 11±0.04 sec. In F3 formulation the most drug release of 97.30% in 30min. Good preparation F3 exhibits r² value of 0.980.