Future Journal of Pharmacy and Medical Sciences

Formulation and Optimization of Propranolol Hydrochloride Oro-dispersable Tablets by Central Composite Design

2024-07-26T10:06:28+0530

The present work aimed to formulate and optimize propranolol HCL mouth tablets through experiment design. The scientific knowledge of input and output factors was assessed using the central composite design tool to create a design space for regulatory flexibility. The natural super disintegrant concentrations were chosen as the independent variables. The dependent variables were in vitro dispersion time and drug release %. FTIR tests showed drug and excipient compatibility. Precompression parameters showed that the flow characteristics were generally good. The direct compression method was used to manufacture the tablets, and all of the tablets made in the tests above met the predetermined limitations for pharmacotechnical characteristics. Dehydrated banana powder concentration increases led to a reduction in in vitro dispersion time and an increase in drug release percentage. According to kinetic studies, drug release from all formulations followed the first-order release. The outcomes proved that the suggested concept for creating Propranolol Hcl Mouth Melt Tablets with optimal qualities worked well.

Development and bioavailability improvement of imiquimod in the form of solid lipid nanoparticles

2024-07-23T13:16:20+0530

Nanomaterials are the ideal carriers for biological applications because of their high bioavailability and biocompatibility. The primary focus of many researchers employing novel techniques has been fresh discoveries. Many methods have been used to create nanoparticles, which have potential applications in various illnesses. Solid Lipid Nanoparticle (SLN) drug delivery system has outstanding results in treating chronic diseases. Actinic keratoses (AK), known as sun keratoses or senile keratoses, are benign intraepithelial neoplasms caused by abnormal keratinocyte proliferation. Hence, in the present research, Imiquimod SLNs were fabricated using various concentrations of lipids, surfactants, and cryoprotectants. Cold high-pressure homogenization was shown to produce smaller particles with improved entrapment effectiveness. The Particle size ranges from (209.6±4.57 to 502.1±8.9 nm). Formulation IMB 3 which contain 1% w/w Glycerol Monostearate and 3% w/w Glyceryl Behenate as Lipid for SLNs preparation shows better results for Mean particle size (245.1±8.45), Zeta Potential (-41±1.2), PDI (0.39±0.03), % EE (64±0.79) and Loading Capacity (48±2.6) with % cumulative drug release of 89.74±3.5 after 24 hours.

Scurvy - Rediscovering a Forgotten Disease

2024-07-23T13:07:34+0530

Scurvy is a long-documented dietary deficit that results from inadequate vitamin C. Because of its part in the metabolic events of connective tissue production, it results in a diverse presentation that affects numerous organ systems. Prominent signs and symptoms include ecchymoses, arthralgias, skin pigmentation, decreased wound healing, and gingival bleeding. Due to increased consumption as well as supplementation of vitamin C, the incidence of scurvy has drastically decreased in contemporary times; yet, isolated cases still arise. It is primarily identified in the elderly and malnourished in industrialised nations, and it is linked to drinking, a low socioeconomic status, as well as unhealthful eating habits. Among other GI symptoms, gastrointestinal (GI) bleeding has been reported to be an uncommon cause of scurvy. Vitamin C supplements can effectively treat and prevent it. A crucial redox co-factor in the systems of plants and animals is ascorbic acid, sometimes known as vitamin C. Although ascorbic acid is produced in sufficient amounts by most species, it functions as a real vitamin in those that lack the enzymes needed for synthesis. A crucial component of several metabolic pathways is ascorbic acid. Ascorbic acid must be obtained by humans from diet. People who eat ascorbic acid-deficient diets get scurvy.