Formulation and Optimization of Propranolol Hydrochloride Oro-dispersable Tablets by Central Composite Design

Abstract

The present work aimed to formulate and optimize propranolol HCL mouth tablets through experiment design. The scientific knowledge of input and output factors was assessed using the central composite design tool to create a design space for regulatory flexibility. The natural super disintegrant concentrations were chosen as the independent variables. The dependent variables were in vitro dispersion time and drug release %. FTIR tests showed drug and excipient compatibility. Precompression parameters showed that the flow characteristics were generally good. The direct compression method was used to manufacture the tablets, and all of the tablets made in the tests above met the predetermined limitations for pharmacotechnical characteristics. Dehydrated banana powder concentration increases led to a reduction in in vitro dispersion time and an increase in drug release percentage. According to kinetic studies, drug release from all formulations followed the first-order release. The outcomes proved that the suggested concept for creating Propranolol Hcl Mouth Melt Tablets with optimal qualities worked well.