Scurvy - Rediscovering a Forgotten Disease

Authors

  • Vidyadhari Arava Department of Pharmacology, Saastra College of Pharmaceutical Education & Research, NearVarigonda Jwalamukhi Temple, Muthukur Raod, Kakupalli, Nellore-524311, Andhra Pradesh, India https://orcid.org/0000-0003-3815-7612
  • Ashok Kumar V Saastra College of Pharmaceutical Education & Research, Near Varigonda Jwalamukhi Temple, Muthukur Raod, Kakupalli, Nellore-524311, Andhra Pradesh, India
  • Teja Divya Mangala Saastra College of Pharmaceutical Education & Research, Near Varigonda Jwalamukhi Temple, Muthukur Raod, Kakupalli, Nellore-524311, Andhra Pradesh, India
  • Divya Sree Bandi Saastra College of Pharmaceutical Education & Research, Near Varigonda Jwalamukhi Temple, Muthukur Raod, Kakupalli, Nellore-524311, Andhra Pradesh, India
  • Pavani Tummala Saastra College of Pharmaceutical Education & Research, Near Varigonda Jwalamukhi Temple, Muthukur Raod, Kakupalli, Nellore-524311, Andhra Pradesh, India
  • Ram Prathap Goud2 Porumamilla Saastra College of Pharmaceutical Education & Research, Near Varigonda Jwalamukhi Temple, Muthukur Raod, Kakupalli, Nellore-524311, Andhra Pradesh, India
  • Siva Prasad Tatiparthi Saastra College of Pharmaceutical Education & Research, Near Varigonda Jwalamukhi Temple, Muthukur Raod, Kakupalli, Nellore-524311, Andhra Pradesh, India
  • Swathi Krishna KV Department of Pharmaceutics, Saastra College of Pharmaceutical Education & Research, Near Varigonda Jwalamukhi Temple, Muthukur Raod, Kakupalli, Nellore-524311, Andhra Pradesh, India https://orcid.org/0000-0003-2224-4172

Keywords:

Signs of scurvy, Scurvy symptoms, Risk Factors, Pathophysiology, Mucosal ooze

Abstract

Scurvy is a long-documented dietary deficit that results from inadequate vitamin C. Because of its part in the metabolic events of connective tissue production, it results in a diverse presentation that affects numerous organ systems. Prominent signs and symptoms include ecchymoses, arthralgias, skin pigmentation, decreased wound healing, and gingival bleeding. Due to increased consumption as well as supplementation of vitamin C, the incidence of scurvy has drastically decreased in contemporary times; yet, isolated cases still arise. It is primarily identified in the elderly and malnourished in industrialised nations, and it is linked to drinking, a low socioeconomic status, as well as unhealthful eating habits. Among other GI symptoms, gastrointestinal (GI) bleeding has been reported to be an uncommon cause of scurvy. Vitamin C supplements can effectively treat and prevent it. A crucial redox co-factor in the systems of plants and animals is ascorbic acid, sometimes known as vitamin C. Although ascorbic acid is produced in sufficient amounts by most species, it functions as a real vitamin in those that lack the enzymes needed for synthesis. A crucial component of several metabolic pathways is ascorbic acid. Ascorbic acid must be obtained by humans from diet. People who eat ascorbic acid-deficient diets get scurvy.

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Published

2024-04-15