Design and characterization of controlled release formulation of Mesna by using different polymers

Abstract

The current study created a controlled-release formulation of Mesna to keep the drug at therapeutic levels for longer than ten hours. Eudragit L 100, Chitosan, HPMC K4M. The dose of mesna was set at 100 mg. The tablet's total weight was calculated to be 100 mg. Polymers were employed in concentrations of 50 mg, 100 mg, and 150 mg. Every formulation passed several physicochemical evaluation criteria and was determined to be within tolerances. However, it was clear from the dissolving trials that the formulation (F6) had a better and more desirable drug release pattern, achieving 96.47% in 10 hours. As a controlled release substance, it contains the naturally occurring polymer Mesna. The release kinetics mechanism was in zero order. The optimal formulation was used again for reproducibility, and conformance was tested in all quality control procedures. It was discovered that the outcomes were very impossible for one another. The optimized formula will be used for formulation development and other studies, such as bio-equivalency research, to ensure a successful product launch.